The Clinical Significance of Troponin

Oct. 27, 2022

According to statistics from the World Health Organization (WHO), there are about 56 million deaths worldwide each year, of which more than 17 million people die from cardiovascular diseases, accounting for more than 31% of all death factors. In China, the prevalence of cardiovascular diseases is on the rise. It is estimated that there are 290 million people suffering from cardiovascular diseases, including 13 million strokes, 11 million coronary heart diseases, 5 million pulmonary heart diseases, 4.5 million heart failures, and rheumatism. There are 2.5 million congenital heart diseases, 2 million congenital heart diseases, and 270 million hypertension.

Cardiovascular disease has a high mortality rate, a high disability rate, extremely high medical costs after illness, and severely impaired quality of life. Therefore, the treatment of cardiovascular disease focuses on early detection and early treatment. Troponin is a marker that reflects myocardial damage. It is a very specific clinical examination and is of great significance for the diagnosis of heart disease.

What is troponin?

Troponin (cTn) is a regulatory protein of muscle tissue contraction. It is located on the thin filaments of contractile protein and plays an important regulatory role in the process of muscle contraction and relaxation. It contains 3 subtypes: fast response type and slow response type Type and cardiac troponin (cTn). The increase of cTn in serum reflects the damage of cardiomyocytes, and its specificity and sensitivity are higher than the conventional myocardial enzyme spectrum.


Clinical significance

Troponin determination is mainly used for the laboratory diagnosis of acute myocardial infarction, the prognostic judgment of unstable angina, and the treatment monitoring of thrombolytic drugs after AMI. At the same time, it has certain diagnostic values for other diseases of cardiomyocyte damage.

Troponin is a marker of myocardial injury and necrosis, which has important clinical significance for the diagnosis and risk stratification of acute myocardial infarction. Elevated troponin value indicates myocardial damage, which can be seen in acute myocardial infarction, unstable angina, pulmonary infarction, heart failure, and other diseases that cause myocardial damage such as pancreatitis, connective tissue disease, etc. The higher the value, the wider the damage range In patients with acute myocardial infarction, the release begins in 3 to 6 hours and reaches a peak in 10 to 24 hours. The time to return to normal cTnT and cTnI are 10-15 days and 5-7 days, respectively; some patients with renal insufficiency may also increase.

Elevated troponin combined with evidence of ischemia is helpful for the early diagnosis and treatment of type I myocardial infarction; grasping the changing law of elevated troponin is helpful for the differential diagnosis of elevated troponin. For example, transient myocardial injury caused by strenuous exercise, tachycardia, acute pulmonary embolism, etc., cTn may increase temporarily and return to normal within 1 to 2 days; cTn increase caused by heart failure is chronically increased, these characteristics All help to differentiate from myocardial infarction.

The above information is provided by the pharmaceuticals supplier.